Gender Comparisons and Associations between Lower Limb Muscle Activation Strategies and Resultant Knee Biomechanics during Single Leg Drop Landings

(1) Background: We aimed to compare gender differences in knee biomechanics and neuromuscular characteristics, determine the relationships between lower limb muscle pre-activations during a single leg drop landing, order identify riskier landing patterns prevent injury intervene properly. (2) Methods: Descriptive laboratory cross-sectional study on 38 healthy untrained subjects with low moderate physical activity status. (3) Results: During initial-contact phase of females demonstrated greater peak vertical ground reaction force (GRF) normalized body weight (49.12 ± 7.53 vs. 39.88 5.69 N/kg; p < 0.001; Hedge’s g = 1.37), anterior (0.23 0.04 0.17 0.05 1.33), decreased pre-activation semitendinosus (45.10 20.05% 34.03 12.05%; 0.04; 0.67). The final regression equation was 0.024 + 0.025 (peak flexion moment) − 0.02 (semitendinosus-to-vastus lateralis ratio) 0.003 GRF) (R2 0.576, 0.001). (4) Conclusions: Overall, data provided this support that reduced semitendinosus-to-vastus ratio predicted an increase potentially ACL forces. Female non-athletes had gender-specific characteristics may contribute injury. Future studies are warranted consider more possible predictors non-contact